Impact of AI-assisted Medication Dosing on Adherence, Cognition, and Treatment Perception in Elderly Patients

RESEARCH DIALOGUE REAL-WORLD IMPACT

Contributors

  • Abiha Zainab M.Phil. Scholar, Saulat Institute of Pharmaceutical Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  • Qurat-ul-Ain Zia BS Graduate, Saulat Institute of Pharmaceutical Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
  • Walija Maryum BS Graduate, Saulat Institute of Pharmaceutical Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
  • Hunaina Nadeem BS Graduate, Saulat Institute of Pharmaceutical Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
  • Fiza Iman M.Phil. Scholar, National Institute of Psychology, Quaid-I-Azam University, Islamabad, Pakistan.
Keywords
Medication Adherence Cognitive Performance Medication Management AI-Assisted Medication Elderly Patients

Abstract

The focus of this study is to evaluate the effectiveness of an AI-assisted medication dosing system in improving medication compliance, cognitive function related to medication management, and treatment perception among elderly patients. 80 elderly patients undergo a quantitative, quasi-experimental pretest–posttest design, who received AI-guided dosing recommendations with clinician oversight for 12 weeks. Morisky Medication Adherence Scale (MMAS-8) is used to assess medication adherence, cognitive performance using the Mini-Mental State Examination (MMSE), and Structured Technology Acceptance Questionnaire is used for treatment perception. Pre- and post-intervention scores were compared by using paired sample t-tests and Pearson’s correlation analysis inspects relationships among study variables. The results showed a substantial increase in compliance and therapeutic adherence (pre-intervention mean = 5.42 ± 1.21; post-intervention mean = 7.13 ± 0.96; t = 8.74, p < 0.001), cognitive function (pre-intervention mean = 24.18 ± 2.64; post-intervention mean = 26.03 ± 2.31; t = 6.11, p < 0.001), and treatment evaluation (pre-intervention mean = 3.01 ± 0.54; post-intervention mean = 4.21 ± 0.47; t = 10.38, p < 0.001). Important positive interrelations were observed between adherence and cognitive performance (r = 0.58, p < 0.001), adherence and treatment perspective (r = 0.66, p < 0.001), and cognitive function and treatment performances (r = 0.49, p < 0.001). The conclusion illustrated that AI-assisted medication dosing significantly enhances adherence, cognitive ability for medication management, and patient acceptance, supporting its amalgamation into geriatric pharmacotherapy to enhance its clinical efficacy

References

Campbell, N. L., Boustani, M. A., Skopelja, E. N., Gao, S., Unverzagt, F. W., Murray, M. D., & Callahan, C. M. (2012). Medication adherence in older adults with cognitive impairment: A systematic evidence-based review. The American Journal of Geriatric Pharmacotherapy, 10(3), 165–177. https://doi.org/10.1016/j.amjopharm.2012.04.004

Davis, F. D. (1989). Perceived usefulness, perceived ease of use, and user acceptance of information technology. MIS Quarterly, 13(3), 319–340. https://doi.org/10.2307/249008

DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000). Depression is a risk factor for noncompliance with medical treatment. Archives of Internal Medicine, 160(14), 2101–2107. https://doi.org/10.1001/archinte.160.14.2101

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. https://doi.org/10.1016/0022-3956(75)90026-6

Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V., Waite, L., Seibel, M. J., Handelsman, D. J., Cumming, R. G., & Le Couteur, D. G. (2012). Polypharmacy cutoff and outcomes: Five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989–995. https://doi.org/10.1016/j.jclinepi.2012.02.018

Herrera, A. P., Snipes, S. A., King, D. W., Torres-Vigil, I., Goldberg, D. S., & Weinberg, A. D. (2010). Disparate inclusion of older adults in clinical trials: Priorities and opportunities for policy and practice change. American Journal of Public Health, 100(Suppl 1), S105–S112. https://doi.org/10.2105/AJPH.2009.162982

Insel, K. C., Morrow, D. G., Brewer, B. B., & Figueredo, A. J. (2006). Executive function, working memory, and medication adherence among older adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 61(2), P102–P107. https://doi.org/10.1093/geronb/61.2.P102

Khezrian, M., McNeil, C. J., Murray, A. D., & Myint, P. K. (2020). An overview of prevalence, determinants and health outcomes of polypharmacy. Therapeutic Advances in Drug Safety, 11, 1–10. https://doi.org/10.1177/2042098620933741

Maher, R. L., Hanlon, J., & Hajjar, E. R. (2014). Clinical consequences of polypharmacy in elderly. Expert Opinion on Drug Safety, 13(1), 57–65. https://doi.org/10.1517/14740338.2013.827660

Mangoni, A. A., & Jackson, S. H. D. (2004). Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications. British Journal of Clinical Pharmacology, 57(1), 6–14. https://doi.org/10.1046/j.1365-2125.2003.02007.x

Morisky, D. E., Ang, A., Krousel-Wood, M., & Ward, H. J. (2008). Predictive validity of a medication adherence measure for hypertension control. Journal of Clinical Hypertension, 10(5), 348–354. https://doi.org/10.1111/j.1751-7176.2008.07572.x

Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., … Haynes, R. B. (2014). Interventions for enhancing medication adherence. Cochrane Database of Systematic Reviews, (11), CD000011. https://doi.org/10.1002/14651858.CD000011

Osterberg, L., & Blaschke, T. (2005). Adherence to medication. The New England Journal of Medicine, 353(5), 487–497. https://doi.org/10.1056/NEJMra050100

Sabaté, E. (Ed.). (2003). Adherence to long-term therapies: evidence for action. World health organization.

Serrano, D. R., Luciano, F. C., Anaya, B. J., Ongoren, B., Kara, A., Molina, G., Ramirez, B. I., Sánchez-Guirales, S. A., Simon, J. A., Tomietto, G., Rapti, C., Ruiz, H. K., Rawat, S., Kumar, D., & Lalatsa, A. (2024). Artificial intelligence (AI) applications in drug discovery and drug delivery: Revolutionizing personalized medicine. Pharmaceutics, 16(10), 1328. https://doi.org/10.3390/pharmaceutics16101328

Sutton, R. T., Pincock, D., Baumgart, D. C., Sadowski, D. C., Fedorak, R. N., & Kroeker, K. I. (2020). An overview of clinical decision support systems: Benefits, risks, and strategies for success. Journal of Biomedical Informatics, 109, 103466. https://doi.org/10.1016/j.jbi.2020.103466

Topol, E. J. (2019). High-performance medicine: The convergence of human and artificial intelligence. Nature Medicine, 25(1), 44–56. https://doi.org/10.1038/s41591-018-0300-7

World Health Organization. (2003). Adherence to long-term therapies: Evidence for action. WHO.

World Health Organization. (2018). Ageing and health. WHO. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health

Corresponding Author

Abiha Zainab

M.Phil. Scholar, Saulat Institute of Pharmaceutical Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Corresponding Author: [email protected]

How to Cite

Zainab, A., Zia, Q.- ul-A., Maryum, W., Nadeem, H., & Iman, F. (2026). Impact of AI-assisted Medication Dosing on Adherence, Cognition, and Treatment Perception in Elderly Patients. The Regional Tribune, 5(1), 300-309. https://doi.org/10.55737/trt/v-i.226